Ilifu, a big data infrastructure for data-intensive research, enables South African researchers to be world leaders in the strategic science domains of astronomy and bioinformatics. Hosted at the UCT ICTS and operated by IDIA on behalf of a consortium of universities and research organisations, ilifu is a node in the national data infrastructure, partly funded by the Department of Science and Innovation to support the National Integrated Cyberinfrastructure System of South Africa.